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However, significant translational barriers remain: no human pharmacokinetic data, high synthesis cost, unknown long-term safety, and the absence of clinical trials

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This can lead to diabetes, neurological conditions like Parkinsons, and even cancer

Despite these limitations, GO remains the most widely adopted ontology for functional annotation and enrichment in omics workflows, particularly when used in combination with other annotation systems in multi-omics analyses

Wu X, Yao Z, Zhao L, Zhang Y, Cao M, Li T, et al

Although this compensatory response may have confounded measurement of the true contribution of HSL to adipose fatty acid mobilization, it is clear from a number of studies that HSL is not strictly required for the initiation of TAG hydrolysis