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GLP-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease

doi:10.1089/ars.2007.1639 39

Obesity is a key driver of the most prevalent cardiometabolic diseases, serving as a critical factor in the development of cardiovascular disease, such as ischemic heart disease and stroke [11], and constituting the leading modifiable cause of type 2 diabetes [12]

Short-term results are likely to be more modest and may not reflect the full potential of treatment

P.Mousavi KhaneghahA.et al (2025)

In DKD, ERS is primarily triggered by hyperglycemia, proteinuria, and the presence of AGEs and free fatty acids ( A recent study has revealed that ERS can increase the levels of unsaturated triacylglycerol precursors and reduce lipid droplet formation, leading to tubular injury and fibrosis in renal proximal tubular cell lines and STZ-induced diabetic mouse kidneys (83)