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Ensuring the continuous involvement of patients, including at the European Medicines Agency, will be key to ensure this

In a study of 22 children with UCDs who survived a hyperammonaemic coma, the duration of coma was inversely correlated with the childrens IQ at 12 months after recovery from the hyperammonaemic coma 27,28

This can be seen as a problem due to lack of standardization or as a feature that actually makes the findings more robust: whatever design flaws exist in one study are probably absent from the rest

Part II: Risk factors

Severe hypoglycemia can cause confusion, loss of consciousness, seizures, and can be life-threatening