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Individuals with null genotypes for GSTM1 or GSTT1 (i.e., they lack functional copies of these genes) exhibit a markedly different pharmacokinetic profile

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Starting at a lower dose and increasing gradually helps assess tolerance and minimize any initial digestive discomfort

Current guidance suggests holding therapy before certain procedures, yet decisions must remain individualized

They generally include coaching with a pharmacist or nurse who provides nutrition and health information, as well as information on lifestyle and exercise