Reactive astrocytes as therapeutic targets for CNS disorders
Most importantly, individuals with MS experience severe disabling fatigue [229], with 70% of patients with MS reporting fatigue38% of which describe fatigue to be their most disabling symptom [230]
Diabetes can be broadly categorized into two types: type 1 diabetes, which is characterized by the lack of insulin secretion from the pancreas, and type 2 diabetes, which involves increased insulin resistance despite insulin secretion from the pancreas, elevating the blood glucose levels [182,183,184]
Basic symptoms and ultrahigh risk criteriasymptom development in the initial prodromal state
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