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In a remarkably streamlined regulatory mechanism, it orchestrates systemic iron flux by binding to the only known mammalian cellular iron exporter (ferroportin) on the surface of iron-releasing cells (macrophages and enterocytes), blocking cellular iron release into the circulation

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Likewise, another dualAG named cotadutide (MEDI0382) was more effective than obeticholic acid in improving liver metabolism and ameliorating MASH and fibrosis in C57BL/6J or ob/ob mice on a high trans-fat/fructose/cholesterol diet 14 , as well as decreased liver inflammation and apoptosis in adipocytes 15

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doi: 10.4049/jimmunol.169.1.10 77 MurthyKGDebAGoonesekeraSSzaboCSalzmanAL