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The most pronounced differences were observed across gastrointestinal and metabolic events, including nausea (9,651 vs 38,030), vomiting (4,383 vs 17,062), pancreatitis (1,389 vs 6,655), and hypoglycaemia (773 vs 1,778), all substantially lower with combination therapy (Table 1)

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Pregnant or breastfeeding women, people with copper metabolism disorders like Wilsons disease, and anyone with active skin infections should speak with a doctor before starting

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Combination protocols: Some studies pair Cagrilintide with semaglutide (GLP-1 agonist), where the two together outperform either therapy alone in weight reduction

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