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Additionally, it has been shown to decrease wrinkles and fine lines while also increasing skin suppleness

By targeting IL-1, interleukin-18 (IL-18), and type I interferon pathways, probiotics can fine-tune inflammasome activity, thereby suppressing aberrant inflammatory responses while simultaneously strengthening host antiviral defenses (236)

Int J Mol Sci 19:447

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This means preserving muscle during weight loss with semaglutide may be important to reduce insulin resistance and prevent frailty in people with obesity. Haines said that more studies are needed to find the best way to lose fat but keep muscle when using GLP-1 medications.

Semaglutide further augments this effect by slowing down gastric emptying and increasing the feeling of fullness