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General: Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment

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9 This in turn promotes the accumulation of reactive oxygen species

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Ligament healing studies demonstrate similar benefits, with BPC-157 showing consistent functional, biomechanical, macroscopic, and histological improvements

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