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The article, Glucagon Like Peptide-1 (GLP-1) Receptor Agonists: There Is No Such Thing as a Free Lunch published in the The American Journal of Medicine provides a healthy glimpse of reality with GLP-1 drug use

This reduced appetite can lead to a decrease in calorie consumption, contributing to weight loss

Originally developed for managing type 2 diabetes by helping regulate blood sugar, this innovative class of medications has increasingly become recognized for its substantial effectiveness in promoting weight loss and overall metabolic health

The earlier TRIUMPH-4 osteoarthritis trial reported 20.9% on the same dose

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This included Richard Goodman (figure 22) who after completing a BSc degree in chemistry at MIT had done an MD and PhD at the University of Pennsylvania and then trained in clinical medicine at Tufts-New England Medical Centre