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The molecular mechanisms of the neuroprotective effects of GLP-1R agonists include signaling pathways such as ERK signaling, PI3K signaling, RhoA activity, MAPK/NF-B signaling, and the Epac/Akt pathway

In recent years, it has also been spotlighted for its effectiveness in weight management

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Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, et al: Extension of life-span with superoxide dismutase = catalase mimetics

"So it's very challenging," Yacawych says, "to be able to separate these side effects, like nausea, from GLP-1's intended effects, like weight loss." A possible workaround came from a team led by Ernie Blevins of the University of Washington

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