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We used an Ultimate 3000 HPLC system (Dionex) with a Waters Acquity CSH C18 1.7 m 1 150 mm column on operating at a flow rate of 30 l/min with two buffer lines as previously described 23

KPV suppresses pro-inflammatory cytokines at the mucosal and systemic level

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The topical route is the format with the strongest human clinical trial evidence for skin outcomes, from the landmark 1998 Abdulghani study that outperformed both vitamin C and tretinoin to the Finkley skin-thickness data

Okur MN, Fang EF, Fivenson EM, Tiwari V, Croteau DL, Bohr VA (2020) Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD(+) signaling