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Moreover, the levels of NLRP3, IL-1, and IL-18 were also markedly upregulated after HLI, among which IL-1 and IL-18 markedly increased at the 5th day post-HLI, then decreased since the 7th day, indicating the inflammatory reaction peaked at the 5th day (Fig

Injection site reactions were reported for all 11 participants in the LEPR trial