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First, titration strategies are now grounded in real Phase 3 dose-response data rather than Phase 2 extrapolation

By February 2026, eight GLP-1 RAs have received FDA approval, primarily for glycemic control in T2D and chronic weight management in obesity, with expanding cardiovascular (CV) benefits demonstrated in large-scale trials

When ferritinophagy activation and/or HO-1 overexpression increase free iron levels, it leads to an accumulation of lipid peroxides and ferroptosis

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