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According to results published in NEJM, Mounjaro achieved A1C reductions of 2.01% (5mg), 2.24% (10mg), and 2.30% (15mg) versus 1.86% with semaglutide 1mg
Anti-oxidant Activity Various neurodegenerative diseases are characterized by decreased mitochondrial activity, reduced oxidative phosphorylation, and increased reactive oxygen species (ROS) production in the CNS (Starkov, 2008)
A practical default is to treat most reconstituted peptide solutions as short-term materials: refrigerate at 2-8 C , protect from light, minimize vial punctures, and plan to use or discard the vial within about 28 days unless the supplier provides compound-specific stability data
In the 1960s, Maibach and Kligman 16 analyzed sunless tanner with varying DHA concentrations as a treatment for vitiligo, finding that 5% DHA concentration was satisfactory for White patients, while up to 30% concentration was necessary for Black patients
Until those results are in, the recommendation is extrapolated from non-pharmacologic weight-loss literature plus 2024-2025 case reports of GLP-1 patients who lifted and held their lean mass [11]
There are some potential biases in these data that we need to be cautious about, but this gives us some valuable insights about the risk profile of these agents that can inform subsequent studies perhaps even a randomized controlled trial that can tease out the specific mechanisms and provide more conclusive evidence. Reduced risk overall GLP-1 receptor agonists have been approved in the United States to treat diabetes since 2005 and obesity since 2014
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