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This difference may be due to the fact that GLP-1R in the CNS is predominantly located on neurons and GLP-1R in the heart is predominantly located on P cells, and the physiological functions of the two types of cells are very different

LIPOSOMAL TECHNOLOGY

The Effect of Short-Term Hyperglycemia on the Innate Immune System

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We propose that GLP-1 analogs are superior to DPP-4 inhibitors for managing pasireotide-induced hyperglycemia because GLP-1 analogs, unlike DPP-4 inhibitors, spare pasireotide-induced depletion of endogenous GLP-1 and restore insulin secretion suppressed by pasireotide through GLP-1R-Gs activation, counteracting the SSTRs-Gi axis