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In women with an intact uterus, progesterone provides the essential endometrial counterbalance that makes sustained estrogen therapy safe

The Centers for Disease Control and Prevention also highlights how chronic physical stress worsens overall mental distress and fatigue

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People assume that they need to feel unwell (on these medications), but thats not how these meds should work, Sowa says

The mean changes from baseline to week 30 were -1.2 kg, -3.5 kg, and 6.0 kg in the placebo, OZEMPIC 0.5 mg, and OZEMPIC 1 mg arms, respectively

Watch for unexpected drops that could suggest additive glucose-lowering [9]