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The oxidative metabolism of EtOH by alcohol dehydrogenase (ADH) and cytochrome P450 2E1 (CYP2E1) leads to the rapid accumulation of NADH, changing the NAD + /NADH ratio, effectively downregulating FA oxidation and leading to a metabolic shift favoring FA synthesis (Donohue Jr., 2007)

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Microbiome and chronic wound infections: mechanisms and interventions Building upon the clinical challenges outlined in the introduction, this section explores the central role of the microbiome in chronic infections and its disruption in wound healing