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In addition to these genes, upstream signaling pathways such as AMPKmTOR and PPAR have been shown to regulate the transcriptional activity of steroidogenic genes like STAR and HSD3B, directly or indirectly through epigenetic enzymes such as EZH2 ( Table 1 ) (41)

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The changes in histone acylation, mediated by ThDP-dependent 2-oxo acid dehydrogenase complexes, provide a mechanism for thiamine-dependent transcriptional regulation

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