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2 MASLD is primarily characterized by abnormal lipid accumulation in hepatocytes, typically presenting as simple steatosis

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Astbury, J

2014;306:E137887

Three components of aliphatic GSLs like 4MSOB (4-methylsulfinylbutyl glucosinolate), 6MSOH (6-methylsulphinylhexyl glucosinolate) and 8MSOO (8-methylsulphinyloctyl glucosinolate) reduced in gstu20 mutant but maintained wild type level in gsts11 leaves (Figures 4, 5), indicating that GSTU20 plays a greater role in GSL biosynthesis than GSTF11

In contrast, cancers with high expression of only one or two enzymes display metabolic flux redirection or environmental dependence, requiring combination strategies targeting transporter bypass pathways or microenvironmental remodeling cascades