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Notably, probiotics have shown considerable promise in reducing the incidence of certain cancers, especially colorectal and bladder cancer (296, 297)

Given these transcriptomic and biochemical changes, we next asked whether melatonin altered real-time cellular metabolism

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Nevertheless, challenges persist owing to the non-specificity of Kla-associated enzymes, cellular heterogeneity within TME subsets, and unresolved safety profiles of metabolic inhibitors