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Additionally, catalpol protects retinal pigment epithelial ARPE-19 cells from oxidative stress through activation of the Keap1/Nrf2/ARE pathway and the inactivation of oxidative stress-mediated apoptotic pathways (You et al., 2021)

These objective markers are more reliable than subjective assessments, which are susceptible to expectation bias

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Neither compound has published the kind of long-term hard-outcome data (cardiovascular events, mortality) that ultimately defines a metabolic drugs value, because both are too early in development for that

These effects are dose-dependent and typically resolve within 30 to 60 minutes