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That said, the following may occur: Mild water retention or bloating Headaches (from fluid shifts or blood pressure changes) Temporary hunger increases (due to GH release) Injection site irritation Cortisol & Prolactin Unlike older GHRPs like GHRP-2 or GHRP-6 , Ipamorelin does not significantly raise cortisol or prolactin , two hormones associated with water retention, fatigue, gynecomastia, and mood instability

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Avoid taking it close to bedtime as NAD elevation may impact circadian signaling

Nerve irritation if injected improperly

311,981,984 Combining the calcium channel blocker amlodipine with iron chelation therapy may enhance the efficacy of iron chelation, and provide a novel strategy for preventing and treating cardiac iron overload in patients with thalassemia