Arabidopsis thaliana -glutamylcysteine synthetase is structurally unrelated to mammalian, yeast, and Escherichia coli homologs
While glutathione is naturally occurring, individual needs vary
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These activated intermediates are then incorporated into membrane phosphatidylethanolamines (PEs) by lysophosphatidylcholine acyltransferase 3 (LPCAT3), generating the highly oxidizable species AA-PE and AdA-PE ( The intracellular GSH-GPX4 axis constitutes the core antioxidant defense mechanism against ferroptosis
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