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On one hand, such stimuli can activate the IKK complex (IKK/IKK/IKK) through pathways like TNF-R1TRAF2 or ROS-RIPK1

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Evaluation of poly (2-oxazoline) derivatives as poly (ethylene glycol) alternatives, Master Thesis, Ghent University, 2012

The protective effect of SFN appears to be NRF2-dependent, as NRF2 deficiency exacerbated psoriasis-like symptoms, as well as the inflammatory response and abnormal proliferation of keratinocytes in the mice, and SFN had little therapeutic effect in the IMQ-modeled knockout mice

Nayan Patel: Right

The focus is on reducing inflammation and addressing the underlying causes of the autoimmune response