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These obstacles differ completely between oral and injectable routes

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Guinea pigs exposed to 3% PGN in their drinking water for up to 28 days not only displayed the typical histopathological lesions in the caecum and macrophage infiltration in the lamina propria, but also significantly elevated levels of prostaglandin E2 at 2, 4 and 28 days, and elevated levels of leukotriene B4 at day 28 (Marcus et al