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Apart from the coding region, variable 5 and 3 noncoding regions (UTR) were identified, resulting in transcript heterogeneity

Nevertheless, deficiency or oxidation of L-arginine and tetrahydrobiopterin (BH 4 ), which are two essential cofactors for eNOS action, are associated with the uncoupling of the L-arginine-NO pathway that results in the decreased formation of NO and increased eNOS-mediated generation of superoxide

But trials would have to be enormous to exclude an increased risk, and unless the rules change radically by the time they are to be reported, most of the data will remain hidden from independent scrutiny

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Expectant mothers: respect the expiry date