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That's not a criticism of the design - it's a clarification of what the tool is

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The safety and efficacy of once daily LANTUS administered pre-breakfast or at bedtime were also evaluated in a randomized, active-controlled clinical study (Study I, n=697) in patients with type 2 diabetes not adequately controlled on oral antidiabetic therapy

An optimal range is typically considered to be 7-9 mol/L

Children under 12 years: Ask a doctor

There is an optimal dosing range below which effects are minimal and above which effects actually diminish