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This result was replicated in a similar but larger investigation ( N = 1,735) comparing all available GLP-1RAs versus non-GLP-1RA antidiabetics, with this antidepressant association possibly correlating with changes in markers of systemic inflammation (that is, high-sensitivity C-reactive protein) 192

The researchers found that when participants took semaglutide, they saw the following improvements: 42 percent lower risk of psychiatric-related hospital care and sick leave 44 percent lower risk of worsening or new depression 38 percent lower risk of worsening or new anxiety 47 percent lower risk of substance use disorder diagnosis or treatment Other GLP-1 drugs showed more variable effects: Liraglutide was linked to a lower risk of worsening depression but not anxiety