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Regarding the complex neurobiology of NO in depression, studies reveal that maintaining NO within its physiological range is the most probable therapeutic strategy (10)

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Coull JAM, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, et al

As a result, drawing precise conclusions about complex processes, such as fat oxidation, lipid metabolism, and overall energy balance, becomes a significant challenge in controlled research settings

Hypothyroidism slows gut motility, creating conditions for bacterial overgrowth

Your cells become more efficient at using stored fat for fuel (ketosis-like state), and your appetite regulation stabilizes at a new baseline