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In vivo tumorigenicity and tumour metastasis assay Six-week-old male severe combined immunodeficiency (SCID) mice were purchased from Vital River Laboratory Animal Technology (Beijing, China) and raised in an accredited Specific Pathogen Free Animal Facility at Chinese PLA General Hospital

In contrast to the short-access model, rats in the extended-access protocol may exhibit reduced sensitivity to LIRs modulation of dopamine-driven reinforcement, suggesting that more intensive or selective interventions would be needed to produce a behavioral effect

Semaglutide belongs to a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs)

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Key distinctions include: GHK-Cus advantage lies in its well-characterized sequence, reproducible gene expression profile, and dual action on both synthesis and degradation pathways