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Yoshino et al., 2021

Pre-surgical (pre-habilitation) phase: For patients with existing soft tissue or joint pain (e.g., knee, shoulder) entering surgery, PDA may help reduce baseline pain and improve tissue condition, which in turn could help improve pre-operative mobility and strength

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With high antigen-presenting capacity, they secrete reactive oxygen species (ROS) and proinflammatory cytokines, including IL-1, IL-6, IL-12, IL-18, IL-23, and TNF-, which modulate Th1-mediated antigen-specific inflammatory responses (85, 86)