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In vivo investigations corroborated the in vitro results, demonstrating that Au@miR-183i NCs effectively targeted tumors, induced robust ICD, and significantly enhanced PD-L1 immunotherapy, finally eliciting a vigorous systemic anticancer immune response in mice models with HCC [317]

You'll likely notice improvements within 30-60 minutes, with benefits lasting 24-72 hours

It may also enhance the effects of some medications, which could result in adverse effects