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In excess, these highly-reactive species cause oxidative stress which is responsible for significant cell damage

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This property is directly related to its gastric origin: it resists enzymatic degradation in the stomach, which opens the door to oral administration a considerable advantage over other peptides that strictly require injection

Quercetin significantly contributes to the regulation of gut microbiota through its ability to enhance the intestinal microenvironment, decrease the Firmicutes / Bacteroidetes ratio, augment the population of beneficial bacteria like Akkermansia and Flavobacterium , elevate the levels of SCFAs, and inhibit abnormal glucose metabolism-induced aberrant activation of TLR-4/NF-B signaling (Wu et al., 2024)

For thousands of years, humans sought out calorie-dense foods, stored extra energy as fat, and overate when food was available