For example, individuals with CKD often show reduced glutathione levels, which can exacerbate oxidative stress and contribute to further kidney damage
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This hypothesis is anchored on the observations that GIP is a target of PPAR, a master regulator of adipogenesis (174), the expression of GIP increases during adipocyte differentiation (175, 176), and that knockdown of GIPR impairs adipocyte development (175)
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