However, some sex-specific considerations are worth noting: Testosterone and hormonal health: Significant weight loss achieved through these agents may lead to improvements in testosterone levels in men with obesity-related hypogonadism
Every milligram matters
in 2022, Martins & colleagues showed that women with overweight who experienced an average weight loss of 16% had a metabolic adaptation of approximately ~50kcal/day. Meaning, while metabolic adaptation does occur, its not likely the primary culprit of a stalled diet
These are based on FDA-approved active ingredients, and legitimate compounding pharmacies can legally produce customized formulations that are not essentially copies of the brand-name products
However, it is still less cost-effective than exenatide (ICER: $75,971.79/QALY)
We've been very thoughtful about entering into the space," he added