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The post says clearly that depression treatment is not an FDA-approved indication for tirzepatide or other GLP-1 receptor agonists, and its evidence table repeats that there is no FDA-approved indication for depression

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(2003) Ghrelin: a gut-brain hormone: effect of gastric bypass surgery

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The pathophysiology is thought to involve increased sensitivity to cholecystokinin (CCK), leading to excessive gallbladder contractility