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Safety Unknowns : Lack of sterility testing increases infection risk, while unknown interactions with added ingredients create unpredictable side effects

Certain individuals are more likely to experience melena due to underlying health factors or exposures, such as: Older adults age-related changes and medication use make bleeding more likely and symptoms easier to overlook

Participants indicated feeling healthier overall

Importantly, however, particle design governs risk: surface-displayed antigens or certain chemistries can raise immunogenicity and, in rare cases, provoke severe hypersensitivity (including anaphylaxis), whereas encapsulation strategies tend to blunt immediate antigen recognition and are therefore often safer in vivo (206, 208)

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