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Psychological adjustment does not automatically parallel somatic change: in obesity, perceived stress mediates the association between bodyimage disturbance and depressive symptoms [72], and after bariatric surgery, improvements in depression appear to be mediated by bodyimage change rather than weight loss per se [73]

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The primary pathway involves amplification of glucose-triggered insulin production by pancreatic beta cells, which enhances adipose tissue nutrient uptake and reduces circulating free fatty acid flux to the liver [28]

A recent poll among older adults found that 63 percent of people ages 50 to 80 who say they are overweight are interested in taking prescription weight loss medications