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These gastrointestinal symptoms are relatively common, particularly during the first few weeks or after a dose increase, though they are not the only side effects reported

Sci ., 2006 , 47 (9), 3951

Lipopolysaccharides (LPS) are components of the cell wall of Gram-negative bacteria that act as endotoxins, and are known to stimulate an acute phase response (APR) in mammals (3)

Jastreboff et al., 2023 (NEJM): estudio fase 2 en adultos con obesidad sin diabetes, reduccin ponderal media de 24.2% a la semana 48 con 12 mg semanales, el mayor efecto reportado para un frmaco incretnico hasta la fecha de publicacin

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This method is important for identifying first-time obesity-related prescriptions for all adolescents, ensuring that we track new treatment initiations while reducing the risk of including on-going prescriptions