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When exposed to electrophiles (i.e., certain antioxidants) or oxidative stress, Keap1 is inactivated

Collectively, our findings demonstrate that GGCT can coordinately regulate both Gln and Glc metabolism and drives cell proliferation via two distinct mechanisms

The study also reported changes in glucose tolerance, insulin sensitivity and circulating insulin

This adaptation is not merely vital for survival but also for facilitating essential metastatic activities as shown in Fig

doi: 10.3945/ajcn.113.082024 565 TanabeYChinoKOhnishiTOzawaHSagayamaHMaedaSet al

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