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The catalytic efficiency ( k cat / K m ) was obtained by plotting turnover rates (s 1 ) versus substrate concentrations and fitting it to the equation y = catEff x /(1 + Inv K m x (1 + x / K i )), where catEff is the catalytic efficiency and Inv K m is 1/ K m

this interference causes a constant activation of epithelial-to-mesenchymal transition and an increased expression of Zeb1 , which has been identified as a potential risk factor for recurrence and poor prognosis in several types of cancers [82, 83]

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