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While retinoids thicken the dermis through collagen stimulation, recent research suggests that prescription-strength tretinoin may thin the epidermis over 12+ months of continuous use, as the forced turnover eventually leads to cellular compaction

Advanced glycation end products finally lead to arterial stiffness, diabetic nephropathy, and endothelial dysfunction

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10.1105/tpc.109.070219 Plant Cell 49 LeaoG