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This opens a possibility to use limited proteolysis as a tool for conformational analysis of proteins, where a very significant role was played by the laboratory of Angelo Fontana, who emphasized that the proteolytic probes can pinpoint the sites of local unfolding in a protein chain (Fontana et al., 1986

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This multi-stage analytical process confirms identity and validates batch consistency across production cycles

This activity is supported by GSK and Pfizer