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DOI: 10.1213/ANE.0b013e3181d41512 stergaard D et al (1989): Adverse Reactions and Interactions of the Neuromuscular Blocking Drugs

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Some of this weaker activity may be due to its rapid dissociation from the activated receptor as compared to estradiol.10 The benefit of this more localized estrogenic action is a decreased impact of vaginal estriol for management of vaginal dryness on the endometrial tissue as compared to other estrogens such as estradiol