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The simplest way is to focus on the three vitamin B12 forms and pathways through which the vitamin functions: Methylcobalamin works in the cell plasma Adenosylcobalamin functions in the mitochondria Hydroxocobalamin takes effect in the blood and cell plasma Methylcobalamin and adenosylcobalamin are known as the bioactive coenzymes of vitamin B12: only in these chemical forms can the vitamin be directly utilised in the body

Nutrients 13(9):2917

G.BanerjeeA.ChauhanB

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However, the lack of strong absorption means you may not experience significant benefits from standard oral forms