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Epimerase activity dysregulation affects MI/DCI ratio, as in PCOS where a defect of MI utilization could impair FSH and insulin signaling

This enabled identification of 13 C-enrichment in the metabolites originating from the catabolism of 13 C-labelled arginine and proline

Bedard PL, Davies MA, Kopetz S , Flaherty KT, Shapiro G, Luke JJ, Spreafico A, Wu B, Gomez C, Cartot-Cotton S, Mazuir F, Micallef S, Demers B, Juric D

Methylmalonic acid (MMA): A more sensitive marker of B12 function

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Specific species of gut microorganisms can produce substances that increase inflammatory processes in the hypothalamus