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DPP-4 inhibitors: Same pathway so should be stopped, no proven benefit together

in: PubMed | Google Scholar | Authorship note: MAS and DM contributed equally to this work

While this appears to be a novel finding (23, 24), abnormal levels of urinary hypoxanthine have been reported in autism and abnormal plasma and urine levels of other purines are noted in some rare monogenic metabolic disorders that are sometimes associated with autism (21, 74, 75)

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Moreover, MEK/ERK signal pathway activated by insulin, which can also be triggered by KRAS mutation, plays an essential role in PDA malignancy and invasion (Wang et al., 2019)