The focus on GLP-1 alone has proven effective, but it also means that some patients may not experience the same level of metabolic improvement as those using Mounjaro
The SURMOUNT-1 trial showed that tirzepatide, a dual GIP/GLP-1 receptor agonist, produced even greater weight loss (up to 20.9% at the highest dose) with proportional reductions in waist circumference
Joint pain (arthralgia) typically appears before the onset of rheumatoid arthritis (RA) and persists irrespective of arthritis severity
Similar results were seen in patients who had originally taken Wegovy, with those taking a placebo pill regaining 62% of their lost body weight, compared to 21% weight regain in those taking orforglipron
This can feel like: Sharp or dull stomach pain Tightness Swelling in the abdomen What helps: Gentle movement (like walking) Staying hydrated Avoiding carbonated drinks 5
It's available as a pill and liquid that's typically taken by mouth once per day