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Other Anti-Obesity Drugs Qsymia was approved in 2012 15 and includes two active agents, phentermine and topiramate, in an extended-release capsule 51

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Many patients experience markedly fewer and less severe gastrointestinal side effects, such as nausea and vomiting, compared to Wegovy

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Other factors, such as sufficient protein intake, sleep quality, age, and the rate of weight loss, also influence how much muscle mass you may retain while taking a GLP-1, Pinto says